omega-Hydroxylation of 15-hydroxyeicosatetraenoic acid by lung microsomes from pregnant rabbits.

Abstract

15-Hydroxyeicosatetraenoic acid (15-HETE) was converted by lung microsomes from pregnant rabbits to a polar metabolite that was identified by mass spectrometry as the 15,20-dihydroxyeicosatetraenoic acid. The formation of the 20- or omega-hydroxylated product was NADPH dependent, with a specific activity of 1.87 +/- 0.53 nmol/min/mg of microsomal protein… (More)

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@article{Okita1987omegaHydroxylationO1, title={omega-Hydroxylation of 15-hydroxyeicosatetraenoic acid by lung microsomes from pregnant rabbits.}, author={Richard T. Okita and Roy J. Soberman and J M Bergholte and Ben Masters and R. Hayes and R. C. Murphy}, journal={Molecular pharmacology}, year={1987}, volume={32 5}, pages={706-9} }