omega-Conotoxin GVIA and nifedipine inhibit the depolarizing action of the fungal metabolite, destruxin B on muscle from the tobacco budworm (Heliothis virescens).

@article{Bradfisch1990omegaConotoxinGA,
  title={omega-Conotoxin GVIA and nifedipine inhibit the depolarizing action of the fungal metabolite, destruxin B on muscle from the tobacco budworm (Heliothis virescens).},
  author={G A Bradfisch and Sarah Louise Harmer},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={1990},
  volume={28 11},
  pages={1249-54}
}
Recent studies on a group of fungal metabolites, collectively called the destruxins, have suggested that these compounds activate calcium influx in insect skeletal muscle. In this study, we have investigated the sensitivity of destruxin B to the voltage-dependent calcium channel antagonists; omega-conotoxin GVIA, nifedipine, diltiazem and methoxyverapamil… CONTINUE READING