oct4-EGFP reporter gene expression marks the stem cells in embryonic development and in adult gonads of transgenic medaka.

@article{Froschauer2013oct4EGFPRG,
  title={oct4-EGFP reporter gene expression marks the stem cells in embryonic development and in adult gonads of transgenic medaka.},
  author={Alexander Froschauer and Mst Muslima Khatun and David Sprott and Alexander Franz and Christiane Rieger and Frank Pfennig and Herwig O. Gutzeit},
  journal={Molecular reproduction and development},
  year={2013},
  volume={80 1},
  pages={48-58}
}
Maintenance of pluripotency in stem cells is tightly regulated among vertebrates. One of the key genes in this process is oct4, also referred to as pou5f1 in mammals and pou2 in teleosts. Pou5f1 evolved by duplication of pou2 early in the tetrapod lineage, but only monotremes and marsupials retained both genes. Either pou2 or pou5f1 was lost from the genomes of the other tetrapods that have been analyzed to date. Consequently, these two homologous genes are often designated oct4 in functional… CONTINUE READING