nvolvement of cyclin D activity in left ventricle hypertrophy in vivo and in vitro

  title={nvolvement of cyclin D activity in left ventricle hypertrophy in vivo and in vitro},
  author={Peter K. Busk and Jirina Bartkova and Claes C. Str\om and Linda Wulf-Andersen and aRebecca Hinrichsen and Tue E. H. Christoffersen and Lucia Latella and Jiri Bartek and Stig Hauns\o and P. Sheikh},
Objective: Cardiac hypertrophy is induced by a number of stimuli and can lead to cardiomyopathy and heart failure. Present knowledge suggests that cell-cycle regulatory proteins take part in hypertrophy. We have investigated if the D-type cyclins are involved in cardiac hypertrophy. Methods: The expression and activity of the D-type cyclins and associated kinases in cardiomyocytes were studied during angiotensin IIand pressure overload-induced hypertrophy in rats ( R tus norvegicus) and in… CONTINUE READING
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