nm23-H1 suppresses invasion of oral squamous cell carcinoma-derived cell lines without modifying matrix metalloproteinase-2 and matrix metalloproteinase-9 expression.

@article{Khan2001nm23H1SI,
  title={nm23-H1 suppresses invasion of oral squamous cell carcinoma-derived cell lines without modifying matrix metalloproteinase-2 and matrix metalloproteinase-9 expression.},
  author={Md Mobarak Hossein Khan and Manabu Yasuda and Fumihiro Higashino and S K Haque and Takao Kohgo and Makoto Nakamura and Masanobu Shindoh},
  journal={The American journal of pathology},
  year={2001},
  volume={158 5},
  pages={1785-91}
}
nm23-H1 is a candidate gene for the suppression of cancer metastasis. Several studies on human breast, hepatocellular, gastric, ovarian, and colon carcinomas and melanomas have shown that reduced nm23-H1 expression was closely related to metastatic progression with poor prognosis. However, the biochemical mechanism by which nm23-H1 suppresses the metastasis has yet to be elucidated. In this study, we analyzed the correlation between nm23 expression, cell motility, and the invasive abilities of… CONTINUE READING