nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer

Abstract

Transforming growth factor-β (TGF-β) signaling and microRNAs (miRNAs) are important gene regulatory components in cancer. Usually in advanced malignant stages, TGF-β signaling is elevated but global miRNA expression is suppressed. Such a gene expression signature is well illustrated in a fibrosis (or mesenchymal) subtype of ovarian cancer (OC) that is of… (More)
DOI: 10.1038/s41467-018-03556-7

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