natriuretic and vasodepressor actions have been studied by intravenous administration in experimental animals as well as man

The effects of the intranasal administration of synthetic alpha-human atrial natriuretic polypeptide (alpha-hANP) were investigated in14anesthetized spontaneously hypertensive rats (SHR; Okamoto-Aoki strain). They were given intranasally synthetic alpha-hANP in distilled water at doses of10ƒÊg/kg, 50ƒÊg/kg and 100ƒÊg/kg. Intranasal application of200ƒÊl of… CONTINUE READING