nNOS Translocates into the Nucleus and Interacts with Sox2 to Protect Neurons Against Early Excitotoxicity via Promotion of Shh Transcription

@article{Zhang2015nNOSTI,
  title={nNOS Translocates into the Nucleus and Interacts with Sox2 to Protect Neurons Against Early Excitotoxicity via Promotion of Shh Transcription},
  author={Dongmei Zhang and Hongmei Wang and Hanzhang Liu and Tao Tao and Ning Wang and Aiguo Shen},
  journal={Molecular Neurobiology},
  year={2015},
  volume={53},
  pages={6444-6458}
}
Cerebral ischemic stroke is a major public health problem leading to high mortality rates and disability in adults. The NMDA receptor (NMDAR)/neuronal nitric oxide synthase (nNOS)/NO-dependent excitotoxicity has been recognized to play an important role in cerebral ischemic stroke pathogenesis. Accumulating evidence suggests that the biological function of nNOS is associated with its ability to couple proteins and its subcellular localization. Previously, we and others determined that nNOS… CONTINUE READING

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