Acta On c o l o g i c a
- Cad, Saúde, Rio Pública, Janeiro De
- tem in Circumpolar Inuit
The rate of non-Ho d g k i n’s lymphomas (NHL) has increased around the world during the last decades. Ap a rt from the role of the human immunodeficiency virus (HIV ) infection in the development of NHL, ex p o s u re to chemical agents like phenoxyacetic pesticides, hair dyes, metal fumes and organic solvents are suspected to be invo l ve d . The present re v i ew evaluates the results of studies that directly or indirectly searched for an association between solvent ex p o s u re and NHL. The selected studies comprised those published from 1979 to 1997, designed to inve s t igate risk factors for NHL, whether specifically looking for solvent ex p o s u re or for general risks in which solvent ex p o s u re could be included. In 25 of the 45 re v i ewed studies (55.5%), fifty-four statistically significant associations between NHL and solvent ex p o s u re related occupations or industries were re p o rt e d . Statistical significance was more frequently shown in studies where solvent ex p o s u re was more accurately defined. In eighteen of such studies, 13 (72.2%) defined or suggested organic solvents as possible risk factors for NHL.