n-Sec1: a neural-specific syntaxin-binding protein.

  title={n-Sec1: a neural-specific syntaxin-binding protein.},
  author={Jonathan Pevsner and Shu Ching Hsu and Richard H. Scheller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={91 4},
We have identified n-Sec1, a rat brain homolog of the yeast Sec1p protein that participates in the constitutive secretory pathway between the Golgi apparatus and the plasma membrane. The rat brain cDNA is predicted to encode a 68-kDa protein with 65% amino acid identity to Drosophila rop, 59% identity to Caenorhabditis elegans unc-18, and 27% identity to Saccharomyces cerevisiae Sec1p. By RNA blot analysis, n-Sec1 mRNA expression is neural-specific. An anti-peptide antiserum directed against… CONTINUE READING
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