n-6 Fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials
@article{Ramsden2010n6FA, title={n-6 Fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials}, author={Christopher E. Ramsden and Joseph R Hibbeln and Sharon F Majchrzak and John M. Davis}, journal={British Journal of Nutrition}, year={2010}, volume={104}, pages={1586 - 1600} }
Randomised controlled trials (RCT) of mixed n-6 and n-3 PUFA diets, and meta-analyses of their CHD outcomes, have been considered decisive evidence in specifically advising consumption of 'at least 5-10 % of energy as n-6 PUFA'. [] Key Method Here we (1) performed an extensive literature search and extracted detailed dietary and outcome data enabling a critical examination of all RCT that increased PUFA and reported relevant CHD outcomes; (2) determined if dietary interventions increased n-6 PUFA with…
275 Citations
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Replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality, and the suggestion of benefits reported in earlier meta-analyses is due to the inclusion of inadequately controlled trials.
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- BiologyThe British journal of nutrition
- 2011
The total body of evidence continues to support the view that higher consumption of n-6 PUFA lowers the risk of CHD, and together with emerging evidence on cardiovascular benefits of ALA, it would be reasonable to recommend increased consumption of both forms of PUFA.
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- 2014
High circulating linoleic acid, but not other n-6 PUFA, was inversely associated with total and CHD mortality in older adults, and lowest risk was evident with highest levels of both.
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- MedicineTrials
- 2014
The mean plasma total DHA concentrations, which were analyzed among all participants as a measure of adherence, increased by more than 100% in the DHA-enriched phase, compared to other phases, demonstrating excellent dietary adherence.
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The evidence is mixed, with differential effects within the n-6 fatty acid series and outcomes are also dependent on ethnicity and background health status, so well designed intervention trials and population based studies in developing country settings on specific n- 6 fatty acid intake and health effects are desired.
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