n-3 fatty acids effectively improve the reference memory-related learning ability associated with increased brain docosahexaenoic acid-derived docosanoids in aged rats.

@article{Hashimoto2015n3FA,
  title={n-3 fatty acids effectively improve the reference memory-related learning ability associated with increased brain docosahexaenoic acid-derived docosanoids in aged rats.},
  author={M. Hashimoto and M. Katakura and Y. Tanabe and Abdullah Al Mamun and Takayuki Inoue and S. Hossain and M. Arita and O. Shido},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1851 2},
  pages={
          203-9
        }
}
We investigated whether a highly purified eicosapentaenoic acid (EPA) and a concentrated n-3 fatty acid formulation (prescription TAK-085) containing EPA and docosahexaenoic acid (DHA) ethyl ester could improve the learning ability of aged rats and whether this specific outcome had any relation with the brain levels of EPA-derived eicosanoids and DHA-derived docosanoids. The rats were tested for reference memory errors (RMEs) and working memory errors (WMEs) in an eight-arm radial maze. Fatty… Expand
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