n-3 Polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism

@article{Rao2007n3PF,
  title={n-3 Polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism},
  author={Jagadeesh Sridhara Rao and Renee N. Ertley and Hyun-Joo Lee and James C Demar and Julia T. Arnold and Stanley I. Rapoport and Richard P. Bazinet},
  journal={Molecular Psychiatry},
  year={2007},
  volume={12},
  pages={36-46}
}
Decreased docosahexaenoic acid (DHA) and brain-derived neurotrophic factor (BDNF) have been implicated in bipolar disorder. It also has been reported that dietary deprivation of n-3 polyunsaturated fatty acids (PUFAs) for 15 weeks in rats, increased their depression and aggression scores. Here, we show that n-3 PUFA deprivation for 15 weeks decreased the frontal cortex DHA level and reduced frontal cortex BDNF expression, cAMP response element binding protein (CREB) transcription factor… CONTINUE READING
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