myo-inositol and D-ribose ligand discrimination in an ABC periplasmic binding protein.

@article{Herrou2013myoinositolAD,
  title={myo-inositol and D-ribose ligand discrimination in an ABC periplasmic binding protein.},
  author={Julien Herrou and Sean Crosson},
  journal={Journal of bacteriology},
  year={2013},
  volume={195 10},
  pages={2379-88}
}
The periplasmic binding protein (PBP) IbpA mediates the uptake of myo-inositol by the IatP-IatA ATP-binding cassette transmembrane transporter. We report a crystal structure of Caulobacter crescentus IbpA bound to myo-inositol at 1.45 Å resolution. This constitutes the first structure of a PBP bound to inositol. IbpA adopts a type I PBP fold consisting of two α-β lobes that surround a central hinge. A pocket positioned between the lobes contains the myo-inositol ligand, which binds with… CONTINUE READING

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