muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits.

@article{Ekberg2006muOconotoxinMS,
  title={muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits.},
  author={Jenny A. K. Ekberg and Angelo Jayamanne and Christopher W Vaughan and Sevda C Aslan and Linda T. Thomas and Jorgen Mould and Roger Drinkwater and Mark D Baker and Bjarke Abrahamsen and John N Wood and David J Adams and Macdonald J Christie and Richard J Lewis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 45},
  pages={17030-5}
}
The tetrodotoxin-resistant voltage-gated sodium channel (VGSC) Na(v)1.8 is expressed predominantly by damage-sensing primary afferent nerves and is important for the development and maintenance of persistent pain states. Here we demonstrate that muO-conotoxin MrVIB from Conus marmoreus displays substantial selectivity for Na(v)1.8 and inhibits pain behavior… CONTINUE READING