mu-opioid receptor-mediated antinociceptive responses differ in men and women.

  title={mu-opioid receptor-mediated antinociceptive responses differ in men and women.},
  author={J K Zubieta and Yolanda R. Smith and Joshua A. Bueller and Yanjun Xu and Michael R. Kilbourn and Douglas M. Jewett and Charles R. Meyer and Robert A. Koeppe and Christian S. Stohler},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={22 12},
Sex differences in the experience of clinical and experimental pain have been reported. However, the neurobiological sources underlying the variability in pain responses between sexes have not been adequately explored, especially in humans. The endogenous opioid neurotransmitters and mu-opioid receptors are centrally implicated in responses to stress, in the suppression of pain, and in the action of opiate analgesic drugs. Here we examined sex differences in the activation of the mu-opioid… CONTINUE READING


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