mu-Opioid receptor agonists differentially regulate the expression of miR-190 and NeuroD.


The agonists of mu-opioid receptor (OPRM1) induce extracellular signal-regulated kinase (ERK) phosphorylation through different pathways: morphine uses the protein kinase C (PKC)-pathway, whereas fentanyl functions in a beta-arrestin2-dependent manner. In addition, the two pathways result in the different cellular location of phosphorylated ERK and the… (More)
DOI: 10.1124/mol.109.060848


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