mtDNA as a Mediator for Expression of Hypoxia-Inducible Factor 1α and ROS in Hypoxic Neuroblastoma Cells

@inproceedings{Kuo2017mtDNAAA,
  title={mtDNA as a Mediator for Expression of Hypoxia-Inducible Factor 1α and ROS in Hypoxic Neuroblastoma Cells},
  author={Chung-Wen Kuo and Meng-Han Tsai and Tsu-Kung Lin and M M Tiao and Pei-wen Wang and Jiin-Haur Chuang and Shang-Der Chen and C T Liou},
  booktitle={International journal of molecular sciences},
  year={2017}
}
Mitochondria consume O₂ to produce ATP and are critical for adaption of hypoxia, but the role of mitochondria in HIF-1α pathway is as yet unclear. In this study, mitochondrial DNA (mtDNA) enriched (SK-N-AS) and depleted (ρ⁰) cells of neuroblastoma were cultured in a hypoxic chamber to simulate a hypoxic condition and then the major components involved in mitochondrial related pathways, hypoxia-inducible factor 1α (HIF-1α) and reactive oxygen species (ROS) were measured. The results showed that… CONTINUE READING
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