mt-Nd2a suppresses reactive oxygen species production by mitochondrial complexes I and III.

@article{Gusdon2008mtNd2aSR,
  title={mt-Nd2a suppresses reactive oxygen species production by mitochondrial complexes I and III.},
  author={Aaron M Gusdon and Tatyana V. Votyakova and Clayton E Mathews},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 16},
  pages={
          10690-7
        }
}
Reactive oxygen species (ROS) play a critical role in the pathogenesis of human diseases. A cytosine to adenine transversion in the mitochondrially encoded NADH dehydrogenase subunit 2 (mt-ND2, human; mt-Nd2, mouse) gene results in resistance against type 1 diabetes and several additional ROS-associated conditions. Our previous studies have demonstrated that the adenine-containing allele (mt-Nd2(a)) is also strongly associated with resistance against type 1 diabetes in mice. In this report we… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Similar Papers

Loading similar papers…