mre11S--a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosis.

@article{Nairz1997mre11SaYM,
  title={mre11S--a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosis.},
  author={Knud Nairz and Franz Klein},
  journal={Genes & development},
  year={1997},
  volume={11 17},
  pages={2272-90}
}
During meiotic prophase the repair of self-inflicted DNA double-strand break (DSB) damage leads to meiotic recombination in yeast. We employed a genetic screen to specifically characterize cellular functions that become essential after this DSB formation. As a result a new allele of MRE11, termed mre11S (for Separation of functions) was isolated that allows initiation but not processing and repair of meiotic DSBs similar to the well-characterized rad50S allele. In contrast, the mre11-1 allele… CONTINUE READING
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