mot-2–Mediated Cross Talk between Nuclear Factor-κB and p53 Is Involved in Arsenite-Induced Tumorigenesis of Human Embryo Lung Fibroblast Cells

@inproceedings{Li2010mot2MediatedCT,
  title={mot-2–Mediated Cross Talk between Nuclear Factor-κB and p53 Is Involved in Arsenite-Induced Tumorigenesis of Human Embryo Lung Fibroblast Cells},
  author={Yuan Li and Yuan Xu and Min Ling and Ye Yang and Shoulin Wang and Zhongqiao Li and Jianwei Zhou and Xinru Wang and Qizhan Liu},
  booktitle={Environmental health perspectives},
  year={2010}
}
BACKGROUND Inactivation of p53 is involved in arsenite-induced tumorigenesis; however, the molecular mechanisms remain poorly understood. OBJECTIVE We investigated the molecular mechanisms underlying the inactivation of p53 and neoplastic transformation induced by arsenite in human embryo lung fibroblast (HELF) cells. METHODS Anchorage-independent growth assays were performed, and tumorigenicity in intact animals was assessed to confirm arsenite-induced neoplastic transformation. We… CONTINUE READING

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We determined the levels and functions of p53 , nuclear factor - kappa B ( NF - B ; a key transcriptional regulator ) , and mot-2 ( a p53 inhibitor ) and their relationships in arsenite - induced transformed HELF cells by two - dimensional electrophoresis , reverse - transcriptase polymerase chain reaction , Western blot , immunofluorescence , and co - immunoprecipitation assays . RESULTS .
We determined the levels and functions of p53 , nuclear factor - kappa B ( NF - B ; a key transcriptional regulator ) , and mot-2 ( a p53 inhibitor ) and their relationships in arsenite - induced transformed HELF cells by two - dimensional electrophoresis , reverse - transcriptase polymerase chain reaction , Western blot , immunofluorescence , and co - immunoprecipitation assays . RESULTS .
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