mitochondrial pathway for biosynthesis of lipid mediators

  title={mitochondrial pathway for biosynthesis of lipid mediators},
  author={Yulia Y. Tyurina and Samuel M. Poloyac and Vladimir A. Tyurin and Alexander A. Kapralov and Jianfei Jiang and Tamil S. Anthonymuthu and Valentina I. Kapralova and Anna S. Vikulina and Mi-Yeon Jung and Michael Wayne Epperly and Dariush Mohammadyani and Judith Klein-Seetharaman and Travis C. Jackson and Patrick M Kochanek and Bruce R. Pitt and Joel S. Greenberger and Yury A. Vladimirov and H{\"u}lya Bayır and Valerian E Kagan},
  booktitle={Nature chemistry},
The central role of mitochondria in metabolic pathways and in cell-death mechanisms requires sophisticated signalling systems. Essential in this signalling process is an array of lipid mediators derived from polyunsaturated fatty acids. However, the molecular machinery for the production of oxygenated polyunsaturated fatty acids is localized in the cytosol and their biosynthesis has not been identified in mitochondria. Here we report that a range of diversified polyunsaturated molecular species… CONTINUE READING
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