miles-apart-Mediated regulation of cell–fibronectin interaction and myocardial migration in zebrafish

@article{Matsui2007milesapartMediatedRO,
  title={miles-apart-Mediated regulation of cell–fibronectin interaction and myocardial migration in zebrafish},
  author={Takaaki Matsui and {\'A}ngel Raya and Carles Callol-Massot and Yasuhiko Kawakami and Isao Oishi and Concepci{\'o}n Rodr{\'i}guez-Esteban and Juan Carlos Izpisua Belmonte},
  journal={Nature Clinical Practice Cardiovascular Medicine},
  year={2007},
  volume={4 Suppl 1},
  pages={S77-S82}
}
The migration of myocardial precursor cells towards the embryonic midline underlies the formation of the heart tube and is a key process of heart organogenesis. The zebrafish mutation miles-apart (mil), which affects the gene encoding a sphingosine-1-phosphate receptor, is characterized by defective migration of myocardial precursor cells and results in the formation of two laterally positioned hearts, a condition known as cardia bifida. The mechanism that disrupts myocardial migration in mil… CONTINUE READING
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