microRNAs in cancer cell response to ionizing radiation.

  title={microRNAs in cancer cell response to ionizing radiation.},
  author={Jennifer R. Czochor and Peter M. Glazer},
  journal={Antioxidants & redox signaling},
  volume={21 2},
SIGNIFICANCE microRNAs (miRNA) have been characterized as master regulators of the genome. As such, miRNAs are responsible for regulating almost every cellular pathway, including the DNA damage response (DDR) after ionizing radiation (IR). IR is a therapeutic tool that is used for the treatment of several types of cancer, yet the mechanism behind radiation response is not fully understood. RECENT ADVANCES It has been demonstrated that IR can alter miRNA expression profiles, varying greatly… CONTINUE READING


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