microRNAs, RNA binding proteins and cancer.

  title={microRNAs, RNA binding proteins and cancer.},
  author={Reuven Agami},
  journal={European journal of clinical investigation},
  volume={40 4},
microRNAs (miRNAs) are genes involved in normal development and cancer. They inhibit gene expression through interaction with 3'-untranslated regions of messenger RNAs, and are thought to control the expression of a large proportion of the protein-coding genome. However, it is becoming apparent that RNA-binding proteins (RBPs) control the biogenesis of miRNAs, their activity and stability. This indicates the existence of interplay between RBPs and miRNAs that affects gene expression and… CONTINUE READING

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