microRNA133a targets Foxl2 and promotes differentiation of C2C12 into myogenic progenitor cells.

@article{Luo2015microRNA133aTF,
  title={microRNA133a targets Foxl2 and promotes differentiation of C2C12 into myogenic progenitor cells.},
  author={Yueqiu Luo and Xiaoxing Wu and Zongxin Ling and Li Yuan and Yiwen Cheng and Jingyang Chen and Charlie Xiang},
  journal={DNA and cell biology},
  year={2015},
  volume={34 1},
  pages={29-36}
}
microRNAs are endogenous noncoding RNA molecules of ∼22 nucleotides that regulate gene function by modification of target mRNAs. Due to tissue specific of miR-133a and miR-1/206 for skeletal muscles, we investigated the role of miR-133a and miR-1/206 in promoting the differentiation of the C2C12 cells. The results show that directly transfecting mature miR-133a, miR-1/206, or combinations (miR-1 and miR-206, miR-1 and miR-133a, and miR-133a and miR-206) into C2C12 cells, respectively, for 5… CONTINUE READING
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