microRNA signals cell fate

Abstract

In signalling networks, a positive-feedback loop can form when a weak or transient signal enhances expression of components of its pathway to amplify or stabilize a particular cellular response. Li and Carthew (Cell 123, 1267; 2005) recently described an alternative, double-negative feedback mechanism in the fly eye that involves interplay of a… (More)
DOI: 10.1038/ncb0206-112

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