microRNA-mediated keratinocyte hyperproliferation in psoriasis vulgaris.

  title={microRNA-mediated keratinocyte hyperproliferation in psoriasis vulgaris.},
  author={Asako Ichihara and Masatoshi Jinnin and Kenichi Yamane and Akihiko Fujisawa and Keisuke Sakai and Shinichi Masuguchi and Satoshi Fukushima and Keishi Maruo and Hironobu Ihn},
  journal={The British journal of dermatology},
  volume={165 5},
BACKGROUND Psoriasis is a chronic inflammatory skin disease characterized by intense proliferation and abnormal differentiation of keratinocytes, although the pathogenesis is still not completely clarified. OBJECTIVES We investigated the mechanism of keratinocyte proliferation seen in psoriasis, focusing on microRNA (miRNA). MATERIALS AND METHODS miRNAs were extracted from tissues and sera of psoriasis, atopic dermatitis and healthy control. To determine pathogenic miRNAs, we performed… CONTINUE READING
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