microRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans.

@article{Bidzhekov2012microRNAES,
  title={microRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans.},
  author={Kiril Bidzhekov and Lu Gan and Bernd Denecke and A Rostalsky and Michael Hristov and Thomas Andreas Koeppel and Alma Zernecke and Christian Weber},
  journal={Thrombosis and haemostasis},
  year={2012},
  volume={107 4},
  pages={619-25}
}
Small non-coding microRNAs (miRNAs) have emerged to play critical roles in cardiovascular biology. Monocytes critically drive atherosclerotic lesion formation, and can be subdivided into a classical and non-classical subset. Here we scrutinised the miRNA signature of human classical and non-classical monocytes, and compared miRNA expression profiles of atherosclerotic plaques from human carotid arteries and healthy arteries. We identified miRNAs to be differentially regulated with a two-fold or… CONTINUE READING