microRNA-Seq reveals cocaine-regulated expression of striatal microRNAs.

  title={microRNA-Seq reveals cocaine-regulated expression of striatal microRNAs.},
  author={Jodi E. Eipper-Mains and Drew D Kiraly and Dasaradhi Palakodeti and Richard E Mains and Betty A Eipper and Brenton R Graveley},
  volume={17 8},
MicroRNAs (miRNAs) are small RNAs that modulate gene expression by binding target mRNAs. The hundreds of miRNAs expressed in the brain are critical for synaptic development and plasticity. Drugs of abuse cause lasting changes in the limbic regions of the brain that process reward, and addiction is viewed as a form of aberrant neuroplasticity. Using next-generation sequencing, we cataloged miRNA expression in the nucleus accumbens and at striatal synapses in control and chronically cocaine… CONTINUE READING