microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

  title={microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus},
  author={Eleonora Leucci and Francesca Patella and Johannes Waage and Kim Holmstr\om and Morten Lindow and Bo T. Porse and Sakari Kauppinen and Anders Henrik Lund},
  booktitle={Scientific reports},
microRNAs regulate the expression of over 60% of protein coding genes by targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their translational inhibition and/or degradation. There is little evidence so far for microRNA-mediated regulation of other classes of non-coding RNAs. Here we report that microRNA-9 (miR-9) regulates the expression of the Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT-1), one of the most abundant and conserved long non-coding… CONTINUE READING
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