microRNA-506 regulates proliferation, migration and invasion in hepatocellular carcinoma by targeting F-spondin 1 (SPON1).

@article{Dai2015microRNA506RP,
  title={microRNA-506 regulates proliferation, migration and invasion in hepatocellular carcinoma by targeting F-spondin 1 (SPON1).},
  author={Wei Dai and Hai-Li Huang and Min Hu and Si-Jie Wang and Hui-Juan He and Nian-Pin Chen and Ming-Yi Li},
  journal={American journal of cancer research},
  year={2015},
  volume={5 9},
  pages={2697-707}
}
  • Wei Dai, Hai-Li Huang, +4 authors Ming-Yi Li
  • Published 2015 in American journal of cancer research
Our previous study indicates microRNA-506 (miR-506) is downregulated in hepatocellular carcinoma (HCC). In the current study, we investigate the effects of miR-506 on proliferation, migration and invasion in HCC. We report that enforced expression of miR-506 inhibits proliferation, migration and invasion in vitro, and suppresses tumor growth in vivo. Conversely, suppression of miR-506 exhibits promoting effects on proliferation, migration and invasion in vitro, and on tumor growth in vivo. In… CONTINUE READING