microRNA-504 inhibits cancer cell proliferation via targeting CDK6 in hypopharyngeal squamous cell carcinoma.

@article{Kikkawa2014microRNA504IC,
  title={microRNA-504 inhibits cancer cell proliferation via targeting CDK6 in hypopharyngeal squamous cell carcinoma.},
  author={Naoko Kikkawa and Takashi Kinoshita and Nijiro Nohata and Toyoyuki Hanazawa and Noriko Yamamoto and Ichiro Fukumoto and Takeshi Chiyomaru and Hideki Enokida and Masayuki Nakagawa and Yoshitaka Okamoto and Naohiko Seki},
  journal={International journal of oncology},
  year={2014},
  volume={44 6},
  pages={2085-92}
}
Our recent study of the microRNA (miRNA) expression signature of hypopharyngeal squamous cell carcinoma (HSCC) revealed that microRNA-504 (miR-504) is significantly downregulated in HSCC tissues, suggesting that this miRNA is a candidate tumor suppressor. However, several previous reports indicated that miR-504 has an oncogenic function through targeting TP53. The aim of this study was to investigate the functional significance of miR-504 in cancer cells and to identify novel targets regulated… CONTINUE READING
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