microRNA-34a is tumor suppressive in brain tumors and glioma stem cells.

@article{Guessous2010microRNA34aIT,
  title={microRNA-34a is tumor suppressive in brain tumors and glioma stem cells.},
  author={Fadila Guessous and Ying Zhang and Alex Kofman and Alessia Catania and Yunqing Li and David Schiff and Benjamin Purow and Roger Abounader},
  journal={Cell cycle},
  year={2010},
  volume={9 6},
  pages={1031-6}
}
We recently found that microRNA-34a (miR-34a) is downregulated in human glioma tumors as compared to normal brain, and that miR-34a levels in mutant-p53 gliomas were lower than in wildtype-p53 tumors. We showed that miR-34a expression in glioma and medulloblastoma cells inhibits cell proliferation, G1/S cell cycle progression, cell survival, cell migration and cell invasion, but that miR-34a expression in human astrocytes does not affect cell survival and cell cycle. We uncovered the oncogenes… CONTINUE READING