microRNA-309 targets the Homeobox gene SIX4 and controls ovarian development in the mosquito Aedes aegypti.

@article{Zhang2016microRNA309TT,
  title={microRNA-309 targets the Homeobox gene SIX4 and controls ovarian development in the mosquito Aedes aegypti.},
  author={Yang Zhang and Bo Zhao and Sourav Saha Roy and Tusar Tirtha Saha and Vladimir A. Kokoza and Ming Li and Alexander S. Raikhel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 33},
  pages={
          E4828-36
        }
}
Obligatory blood-triggered reproductive strategy is an evolutionary adaptation of mosquitoes for rapid egg development. It contributes to the vectorial capacity of these insects. Therefore, understanding the molecular mechanisms underlying reproductive processes is of particular importance. Here, we report that microRNA-309 (miR-309) plays a critical role in mosquito reproduction. A spatiotemporal expression profile of miR-309 displayed its blood feeding-dependent onset and ovary-specific… CONTINUE READING
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