microRNA-21 regulates astrocytic response following spinal cord injury.

@article{Bhalala2012microRNA21RA,
  title={microRNA-21 regulates astrocytic response following spinal cord injury.},
  author={Oneil G. Bhalala and Liuliu Pan and Vibhu Sahni and Tammy L. Mcguire and Katherine A Gruner and Warren G. Tourtellotte and John A Kessler},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 50},
  pages={17935-47}
}
Astrogliosis following spinal cord injury (SCI) involves an early hypertrophic response that serves to repair damaged blood-brain barrier and a subsequent hyperplastic response that results in a dense scar that impedes axon regeneration. The mechanisms regulating these two phases of astrogliosis are beginning to be elucidated. In this study, we found that microRNA-21 (miR-21) increases in a time-dependent manner following SCI in mouse. Astrocytes adjacent to the lesion area express high levels… CONTINUE READING
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