microRNA-21 promotes cardiac fibrosis and development of heart failure with preserved left ventricular ejection fraction by up-regulating Bcl-2.

@article{Dong2014microRNA21PC,
  title={microRNA-21 promotes cardiac fibrosis and development of heart failure with preserved left ventricular ejection fraction by up-regulating Bcl-2.},
  author={Shuguang Dong and Wenhan Ma and Bohan Hao and Fen Hsiang Hu and Lianhua Yan and Xiaofei Yan and Ya Zhou Wang and Zhijian Chen and Zhaohui Wang},
  journal={International journal of clinical and experimental pathology},
  year={2014},
  volume={7 2},
  pages={565-74}
}
The morbidity and mortality of heart failure with preserved left ventricular ejection fraction (HFpEF) were similar to those of systolic heart failure, but the pathogenesis of HFpEF remains poorly understood. It was demonstrated that, in systolic heart failure, microRNA-21 (miR-21) could inhibit the apoptosis of cardiac fibroblasts, leading to cardiac hypertrophy and myocardial fibrosis, but the role of miR-21 in HFpEF remains unknown. By employing cell culture technique, rat myocardiocytes and… CONTINUE READING

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Molecu- The function of microRNA-21 in HFpEF

  • L van Heerebeek, CP Franssen, N Hamdani, FW Verheugt, GA Somsen, WJ. Paulus
  • Int J Clin Exp Pathol
  • 2014
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