microRNA-183 is an oncogene targeting Dkk-3 and SMAD4 in prostate cancer

  title={microRNA-183 is an oncogene targeting Dkk-3 and SMAD4 in prostate cancer},
  author={Koji Ueno and Hiroshi Hirata and Varahram Shahryari and Guoren Deng and Yuichiro Tanaka and Z. Laura Tabatabai and Yuji Hinoda and Rajvir Dahiya},
  booktitle={British Journal of Cancer},
Background:The purpose of this study was to identify prostate cancer (PC) oncogenic microRNAs (miRs) based on miR microarray and to investigate whether these oncogenic miRs may be useful as PC biomarkers.Methods:Initially, we carried out miR microarray and real-time PCR using RWPE-1, PC-3, DU-145 and LNCaP cells. To investigate the function of miR-183, we used a miR-183 knockdown inhibitor in cell growth and wound-healing assays. We used several algorithms and confirmed that they are directly… CONTINUE READING
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