microRNA-17 regulates the expression of ATG7 and modulates the autophagy process, improving the sensitivity to temozolomide and low-dose ionizing radiation treatments in human glioblastoma cells.

@article{Comincini2013microRNA17RT,
  title={microRNA-17 regulates the expression of ATG7 and modulates the autophagy process, improving the sensitivity to temozolomide and low-dose ionizing radiation treatments in human glioblastoma cells.},
  author={Sergio Comincini and Giulia Allavena and Silvia Palumbo and Martina Morini and Francesca Durando and Francesca Angeletti and Luigi Pirtoli and Clelia Miracco},
  journal={Cancer biology & therapy},
  year={2013},
  volume={14 7},
  pages={574-86}
}
ATG7 is a key autophagy-promoting gene that plays a critical role in the regulation of cell death and survival of various cell types. We report here that microRNAs (miRNAs), a class of endogenous 22-24 nucleotide noncoding RNA molecules able to affect stability and translation of mRNA, may represent a novel mechanism for regulating ATG7 expression and therefore autophagy. We demonstrated that ATG7 is a potential target for miR-17, and this miRNA could negatively regulate ATG7 expression… CONTINUE READING
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