microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis.

@article{Kouchkovsky2013microRNA1792RI,
  title={microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis.},
  author={Dimitri de Kouchkovsky and Jonathan H. Esensten and Wendy L. Rosenthal and Malika M. Morar and Jeffrey A Bluestone and Lukas T Jeker},
  journal={Journal of immunology},
  year={2013},
  volume={191 4},
  pages={1594-605}
}
microRNAs (miRNA) are essential for regulatory T cell (Treg) function but little is known about the functional relevance of individual miRNA loci. We identified the miR-17-92 cluster as CD28 costimulation dependent, suggesting that it may be key for Treg development and function. Although overall immune homeostasis was maintained in mice with miR-17-92-deficient Tregs, expression of the miR-17-92 miRNA cluster was critical for Treg accumulation and function during an acute organ-specific… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

The role of microRNAs in lymphopoiesis.

International journal of hematology • 2014
View 9 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 63 references

Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA

A. Ventura, A. G. Young, +7 authors J. R. Stone
2008
View 3 Excerpts
Highly Influenced

Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation.

Proceedings of the National Academy of Sciences of the United States of America • 2012

Similar Papers

Loading similar papers…