microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling.

@article{Yu2010microRNA1I,
  title={microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling.},
  author={Zuoren Yu and Nicole E. Willmarth and Jie Zhou and Sanjay K. Katiyar and Min Wang and Yang Liu and Peter A. McCue and Andrew A. Quong and Michael Phillip Lisanti and Richard G. Pestell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 18},
  pages={8231-6}
}
microRNAs are thought to regulate tumor progression and invasion via direct interaction with target genes within cells. Here the microRNA17/20 cluster is shown to govern cellular migration and invasion of nearby cells via heterotypic secreted signals. microRNA17/20 abundance is reduced in highly invasive breast cancer cell lines and node-positive breast cancer specimens. Cell-conditioned medium from microRNA17/20-overexpressing noninvasive breast cancer cell MCF7 was sufficient to inhibit MDA… CONTINUE READING

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