microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells.

@article{Vigorito2007microRNA155RT,
  title={microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells.},
  author={Elena Vigorito and Kerry Louise Perks and Cei Abreu-Goodger and Sam Bunting and Zou Xiang and Susan L. Kohlhaas and Partha Pratim Das and Eric A Miska and Antony Rodriguez and Allan Bradley and Kenneth G. C. Smith and Cristina Rada and Anton J. Enright and Kai-Michael Toellner and Ian C. M. Maclennan and Martin Turner},
  journal={Immunity},
  year={2007},
  volume={27 6},
  pages={
          847-59
        }
}
microRNA-155 (miR-155) is expressed by cells of the immune system after activation and has been shown to be required for antibody production after vaccination with attenuated Salmonella. Here we show the intrinsic requirement for miR-155 in B cell responses to thymus-dependent and -independent antigens. B cells lacking miR-155 generated reduced extrafollicular and germinal center responses and failed to produce high-affinity IgG1 antibodies. Gene-expression profiling of activated B cells… CONTINUE READING

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