microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer

  title={microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer},
  author={Lijing Zhang and Yujuan Dong and Nana Zhu and Ho Leung Tsoi and Zengren Zhao and Chung Wah Wu and Kunning Wang and Shu Fa Zheng and Simon Siu-man Ng and Francis Ka-leung Chan and Joseph J. Y. Sung and Jun Yu},
  booktitle={Molecular Cancer},
miR-139-5p was identified to be significantly down-regulated in colon tumor tissues by miRNA array. We aimed to clarify its biological function, molecular mechanisms and direct target gene in colorectal cancer (CRC). The biological function of miR-139-5p was examined by cell growth, cell cycle and apoptosis analysis in vitro and in vivo. miR-139-5p target gene and signaling pathway was identified by luciferase activity assay and western blot. miR-139-5p was significantly down-regulated in… CONTINUE READING
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Histone methylationmediated silencing of mir-139 enhances an aggressive phenotype of non-small cell lung cancer [abstract

  • K Watanabe, M Sunohara, +8 authors D Takai
  • Clin Cancer Res
  • 2014
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