microRNA: emerging therapeutic targets in acute ischemic diseases.

  title={microRNA: emerging therapeutic targets in acute ischemic diseases.},
  author={Pasquale Fasanaro and Simona Greco and Mircea Ivan and Maurizio Colognesi Capogrossi and Fabio Martelli},
  journal={Pharmacology & therapeutics},
  volume={125 1},
microRNAs (miRNAs) are 21-23-nucleotide non-protein-coding RNA molecules that act as negative regulators of gene expression, modulating the stability and/or the translational efficiency of target messenger RNAs. This review describes miRNA regulation and function in tissue response to acute ischemia. We focused our attention on a subset of miRNAs that have been found de-regulated in different studies, suggesting that they may represent "master ischemic" miRNAs, playing a pathogenetic role in… CONTINUE READING

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