microPET and autoradiographic imaging of GRP receptor expression with 64Cu-DOTA-[Lys3]bombesin in human prostate adenocarcinoma xenografts.

@article{Chen2004microPETAA,
  title={microPET and autoradiographic imaging of GRP receptor expression with 64Cu-DOTA-[Lys3]bombesin in human prostate adenocarcinoma xenografts.},
  author={Xiaoyuan Chen and Ryan Park and Yingping Hou and M. Joseph Tohme and Antranik H Shahinian and James R. Bading and Peter Selby Conti},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2004},
  volume={45 8},
  pages={
          1390-7
        }
}
UNLABELLED Overexpression of gastrin-releasing peptide (GRP) receptor (GRPR) in both androgen-dependent (AD) and androgen-independent (AI) human neoplastic prostate tissues provides an attractive target for prostate cancer imaging and therapy. The goal of this study was to develop (64)Cu-radiolabeled GRP analogs for PET imaging of GRPR expression in prostate cancer xenografted mice. METHODS [Lys(3)]bombesin ([Lys(3)]BBN) was conjugated with 1,4,7,10-tetraazadodecane-N,N',N",N"'-tetraacetic… CONTINUE READING

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