miRNP:mRNA association in polyribosomes in a human neuronal cell line.

@article{Nelson2004miRNPmRNAAI,
  title={miRNP:mRNA association in polyribosomes in a human neuronal cell line.},
  author={Peter T. Nelson and Artemis G. Hatzigeorgiou and Zissimos Mourelatos},
  journal={RNA},
  year={2004},
  volume={10 3},
  pages={387-94}
}
MicroRNAs (miRNAs) are small regulatory RNAs that control gene expression by base-pairing with their mRNA targets. miRNAs assemble into ribonucleoprotein complexes termed miRNPs. Animal miRNAs recognize their mRNA targets via partial antisense complementarity and repress mRNA translation at a step after translation initiation. How animal miRNAs recognize their mRNA targets and how they control their translation is unknown. Here we describe that in a human neuronal cell line, the miRNP proteins… CONTINUE READING

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