miRNAs in melanoma: a defined role in tumor progression and metastasis.

  title={miRNAs in melanoma: a defined role in tumor progression and metastasis.},
  author={Francesco Mannavola and Marco P. Tucci and Claudia Felici and Stefania Luigia Stucci and Francesco Silvestris},
  journal={Expert review of clinical immunology},
  volume={12 1},
The crosstalk of melanoma cells with components of the microenvironment promotes malignant cell proliferation and spread to distant tissues. Although the major pathogenetic events have already been elucidated, the mechanisms that drive the metastatic behavior of tumor cells are still undefined. MicroRNAs (miRNAs) are small non-coding RNAs that control post-transcriptional gene expression through interconnected kinases upstream of functional genes involved in tumor progression. Here, we review… CONTINUE READING
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