miRNA589 Regulates Epithelial-Mesenchymal Transition in Human Peritoneal Mesothelial Cells

@inproceedings{Zhang2012miRNA589RE,
  title={miRNA589 Regulates Epithelial-Mesenchymal Transition in Human Peritoneal Mesothelial Cells},
  author={Ke Zhang and Hao Zhang and Xun Jie Zhou and Wen-bin Tang and Li Xiao and Ying-hong Liu and Hong Liu and You-ming Peng and Lin Yan Sun and Fu-you Liu},
  booktitle={Journal of biomedicine & biotechnology},
  year={2012}
}
Background. microRNA (miRNA, miR) are thought to interact with multiple mRNAs which are involved in the EMT process. But the role of miRNAs in peritoneal fibrosis has remained unknown. Objective. To determine if miRNA589 regulates the EMT induced by TGFβ1 in human peritoneal mesothelial cell line (HMrSV5 cells). Methods. 1. Level of miR589 was detected in both human peritoneal mesothelial cells (HPMCs) isolated from continuous ambulatory peritoneal dialysis (CAPD) patients' effluent and HMrSV5… CONTINUE READING
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BMP-7 blocks mesenchymal conversion of mesothelial cells and prevents peritoneal damage induced by dialysis fluid exposure.

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