miRNA mutations are not a common cause of deafness.

  title={miRNA mutations are not a common cause of deafness.},
  author={Michael S. Hildebrand and Philip D Witmer and Shunbin Xu and Stephen Newton and Kimia Kahrizi and Hossein Najmabadi and David Valle and Richard J. H. Smith},
  journal={American journal of medical genetics. Part A},
  volume={152A 3},
Mutations in miRNA genes have been implicated in hearing loss in human families and mice. It is also possible that mutations in miRNA binding sites of inner ear targets alter gene expression levels and lead to hearing loss. To investigate these possibilities we screened predicted target genes of the miR-183 miRNA cluster known to be expressed in the inner ear sensory epithelium. In one Iranian family segregating autosomal recessive non-syndromic hearing loss (ARNSHL), we identified a homozygous… CONTINUE READING

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