miRNA let-7e targeting MMP9 is involved in adipose-derived stem cell differentiation toward epithelia

@inproceedings{Ventayol2014miRNALT,
  title={miRNA let-7e targeting MMP9 is involved in adipose-derived stem cell differentiation toward epithelia},
  author={Marina Ventayol and Jos{\'e} Luis Aboal Vi{\~n}as and Anna Rafanell Sol{\`a} and Michael E Jung and Bernhard Br{\"u}ne and Felip P{\'i} and Chrysoula Mastora and Georgina Hotter},
  booktitle={Cell Death and Disease},
  year={2014}
}
miRNA let-7e is involved in stem cell differentiation, and metalloproteinases are among its potential target genes. We hypothesized that the inhibitory action of let-7e on regulation of MMP9 expression could represent a crucial mechanism during differentiation of adipose-derived stem cells (ASCs). ASCs were differentiated with all-trans retinoic acid (ATRA) to promote differentiation, and the effect of let-7 silencing during differentiation was tested. Results indicate that ASCs cultured with… CONTINUE READING
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